The Extrinsic Apoptotic Pathway
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The Extrinsic Apoptotic Pathway
The Extrinsic Apoptotic Pathway
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Draw the following apoptotic pathway, which operates in human immune cells. A death signal is received when a molecule called Fas binds its cell-surface receptor. The binding of many Fas molecules to receptors causes receptor clustering. The intracellular regions of the receptors, when together, bind proteins called adaptor proteins. These in turn bind to inactive molecules of caspase- 8, which become activated and then activate caspase-3. Once activated, caspase-3 initiates apoptosis. | Numerad
Draw the following apoptotic pathway, which operates in human immune cells. A death signal is received when a molecule called Fas binds its cell-surface receptor. The binding of many Fas molecules to receptors causes receptor clustering. The intracellular regions of the receptors, when together, bind proteins called adaptor proteins. These in turn bind to inactive molecules of caspase- 8, which become activated and then activate caspase-3. Once activated, caspase-3 initiates apoptosis. | Numerad
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APOPTOSIS STEPS: Cell Apoptosis happens in a gentle and controlled way that does not negatively affect surrounding cells. A cell will release moisture to dry itself out and condense until fragmentation occurs. There are no morphological changes because the cell does not release into the extracellular environment. Small vesicles called apoptotic bodies are formed to transport the cell contents elsewhere. This allows cells to die gently and not cause any inflammation. Apoptosis is signaled by chro
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APOPTOSIS STEPS: Cell Apoptosis happens in a gentle and controlled way that does not negatively affect surrounding cells. A cell will release moisture to dry itself out and condense until fragmentation occurs. There are no morphological changes because the cell does not release into the extracellular environment. Small vesicles called apoptotic bodies are formed to transport the cell contents elsewhere. This allows cells to die gently and not cause any inflammation. Apoptosis is signaled by chro
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