The Carolina Panthers ' Week 17 matchup against the Seattle Seahawks certainly looks tough on paper. Seattle enters at a strong 12-3 record and as the No. 1 seed in the NFC. But the Panthers have beaten the class of the conference twice before here in 2025, and they can certainly do it again.

The Denver Broncos (12-3) are set to go on the road to face the Kansas City Chiefs (6-9) in Week 17 of the 2025 NFL season at GEHA Field at Arrowhead Stadium on Thursday, Dec. 25. Check out NFL.com's preview (and expert game picks) for the Christmas Day showdown in the video below.

Jacksonville is a 5.5-point favorite in the latest Jaguars vs. Colts odds at DraftKings, and the total comes in at 48.5. The Jags are -257 money line favorites (risk $257 to win $100), while the Colts are +209 underdogs.

The Bills are facing the Eagles for the first time since 2023 and only the fifth time since 2011. In the most recent 2023 matchup, Buffalo lost a close game to Philadelphia in overtime. Eagles kicker Jake Elliott sent it into OT with a 59-yard field goal with just 20 seconds left in the game.

The “FOX NFL Kickoff" crew breaks down what to expect in Sunday's highly anticipated tilt between the Eagles and Bills.