Ubiquitination is a crucial post-translational modification process where the small protein ubiquitin is attached to target proteins, marking them for degradation or altering their function. This ...

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision.

Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with ...

E3 ligases are enzymes that act as molecular "broker" by binding specific target proteins and coordinating the transfer of ubiquitin from an E2 enzyme. As an E3 ligase recognizes only a restricted set ...

The enzyme E3 ligase plays a key role here by acting as a “broker” that mediates the labeling of the proteins to be degraded. A research team at Goethe University Frankfurt has now made the first ...

Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery. This process, known as the ...

Researchers at Baylor College of Medicine and the Broad Institute of MIT and Harvard and clinicians at Washington University in St. Louis have identified biological markers in triple negative breast ...

Codexis is considering shifting from enzyme supply to ECO Synthesis. This way, they could target siRNA as a near-term commercial wedge with engineered ligases. ECO could convert lab projects into GLP, ...

During an oral Spotlight Presentation, Codexis unveiled the successful end-to-end enzymatic synthesis of an entire approved siRNA therapeutic asset, inclisiran. Codexis enzymatically synthesized the ...