Cancer Research

American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...
Frontiers

Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment

Background: There has been limited success of cancer immunotherapies in the treatment of ovarian cancer (OvCa) to date, largely due to the immunosuppressive tumour microenvironment (TME).
The Lancet

Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltration

aDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA bDepartment of Radiology, Washington University School of Medicine, Saint Louis, MO, USA ...
eLife

A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

In this important study, the authors explore ER stress signaling mediated by ATF6 using a genome-wide gene depletion screen. They find that the ER chaperone Calreticulin binds and directly represses ...
C&EN

Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis

Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States ...
The Lancet

The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ

aScience for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 21, Stockholm, Sweden ...
Frontiers

Prostate cancer research: tools, cell types, and molecular targets

Department of Urology, Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, United States The CD cell typing and cell sorting allowed us to demonstrate other ...