Objective: To compare the HMPAO SPECT cerebral perfusion patterns in early and late onset Alzheimer’s disease. Methods: Twenty patients with early onset disease (<65 years) and 44 patients with late ...

OBJECTIVE To analyse the natural history and survival of corticobasal degeneration by investigating the clinical features of 14 cases confirmed by postmortem examination. METHODS Patients with ...

Wallerian degeneration (WD) after ischaemic stroke is a well known phenomenon following a stereotypical time course. Whereas conventional magnetic resonance imaging fails to detect signal intensity ...

Objective To assess the current use of glucocorticoids (GCs) in Duchenne muscular dystrophy in the UK, and compare the benefits and the adverse events of daily versus intermittent prednisolone ...

The word hippocampus comes from late Latin: hippocampus, derived from the Greek words for a horse+sea monster. In mythology it was a sea horse, having two forefeet, with the body ending in a dolphin's ...

OBJECTIVES To establish the link between frontal lobe dysfunction and violent and criminal behaviour, based on a review of relevant literature. METHODS Articles relating evidence of frontal lobe ...

Stiff-person syndrome (SPS) is characterised by progressive rigidity and muscle spasms affecting the axial and limb muscles. Since its initial description in 1956, marked progress has been made in the ...

Objectives: To describe changes in personality after stroke and effects on carers. Methods: A consecutive series of patients was recruited from hospital admissions with stroke. A novel questionnaire ...

Background: The high coincidence of organic vestibular and somatoform vertigo syndromes has appeared to support pathogenic models showing a strong linkage between them. It was hypothesised that a ...

Objective: The aims of this study were to develop models of personality change after traumatic brain injury (TBI) based on information provided by the TBI survivor and a significant other (SO), and to ...

Painful neuropathy is a common and disabling problem in patients with longstanding diabetes mellitus. Tricyclic antidepressant drugs and other chronic analgesics have been beneficial in some ...

Background: Major depression is associated with cognitive deficits, particularly those requiring central executive functioning. Depressed patients also tend to focus on and think about their symptoms ...