Of course, Wyle is no stranger to garnering awards buzz, having earned 5 noms for Outstanding Supporting Actor in a Drama for his excellent work as up-and-coming surgeon Dr. John

Ifeachor hinted at her exit last week when she shared an Instagram post bidding farewell to her character, Dr. Collins

In a statement shared with PEOPLE, Wyle, 54, said of the nominations, including one for outstanding lead actor in a drama series, "I’m humbled and grateful"

Noah Wyle and Katherine LaNasa celebrated their Emmy nominations together from "The Pitt" set while filming Season 2.

The actress who portrayed Dr. Collins in Season 1 announced last week that she would not be returning to the HBO Max drama but said “what a blessing” to participate. She called it an “absolute privilege to play Dr. Heather Collins in such a groundbreaking season and piece.”

The Pitt star and producer Noah Wyle responds to Tracy Ifeachor's departure.

The star of "The Pitt" will compete in the Outstanding Lead Actor in a Drama Series category for the first time. He was last nominated in 1999 for "ER"

While touting The Pitt‘s 13 nominations on Tuesday, Noah Wyle gave a hint about what to expect in season 2 of the HBO Max medical drama. In April, executive producer R. Scott Gemmill, EP John Wells and EP/star Wyle appeared at Deadline’s Contenders TV in April and shared that the next 15 hours of The Pitt will take place over

Noah Wyle broke his silence on his The Pitt costar — and onscreen love interest — Tracy Ifeachor’s surprising exit ahead of season 2. “Truthfully, we loved the actress,” Wyle, 54, told Deadline on Tuesday,

The actress, 40, isn’t returning as Dr. Heather Collins for Season 2 of the hit HBO Max show, “The Pitt.” Sources told TVLine that it was a creative decision, and not Ifeachor’s choice to leave the medical drama. On Wednesday, the British star hinted at her departure.

The hospital that inspired "The Pitt" has the longest wait times in the city, though long visits are common across the major health systems.