R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. This knock-in rat model carries the R47H mutation in the rat Trem2 gene and a humanized Aβ ...
In trying to treat neuroinflammation, scientists need better ways to visualize microglia in the brains of living people. Current microglial PET tracers target the mitochondrial transporter TSPO, but ...
Dear reader, don your deerstalker, for there was an unsolved mystery at the Human Amyloid Imaging conference, held January 12–14 in San Juan, Puerto Rico. Renaud La Joie of the University of ...
Professional Information Associate ProfessorMayo Clinic New PET Tracers Visualize Activated and Homeostatic Microglia 10 Feb 2026 ...
Mounting evidence links infections to a greater risk of dementia, and vaccination to neuroprotection. What underlies this relationship? In a preprint posted to Research Square on January 13, ...
TAF15 first surprised scientists two years ago, when it, instead of its infamous inclusion-mate, FUS, was found to fold into amyloid filaments in people with a rare neuropathological form of ...
People with Parkinson’s disease have α-synuclein clumps in the brain, but these aggregates are not the only thing clogging them up. Constipation plagues many PD patients, often decades before motor ...
If one person is scanned with one tau PET tracer and a second person, somewhere else, with another, can the results be compared? Can studies using different PET tracers be pooled for joint analysis?
Species: Mouse Genes: SNCA Modification: SNCA: Transgenic Disease Relevance: Parkinson's Disease Strain Name: B6;DBA-Tg(Thy1-SNCA)61Ema Genetic Background: (C57BL/6 x DBA/2)F1 (strain of origin) ...
Please see new entry for CP-13 in the AlzAntbodies database.
The center does not accept donations. Collection is limited to participants in longitudinal research projects conducted by the center. Phenotypes collected include Alzheimer's disease, cognitively ...
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