Gut

Macropinocytosis of neutrophil extracellular trap by gastric cancer cells promotes immune escape and peritoneal metastasis

Background Patients with gastric cancer (GC) and peritoneal metastasis (PM) have poor prognoses due to drug resistance and ...
Gut

Neutrophil extracellular traps induced by tumour-derived NGAL reprogram CAF subtypes via ITGA5 to promote tumour progression in pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) is largely refractory to immune checkpoint blockade, owing to its ...
Gut

Impact of initial severity and progression pattern of new-onset diabetes on pancreatic cancer risk: a 15-year longitudinal nationwide cohort study

Background New-onset diabetes (NOD) increases the risk of pancreatic cancer. Previous studies have mainly focused on the ...
Gut

Ustekinumab for fistulising perianal Crohn’s disease: a randomised placebo-controlled trial from the GETAID

Background Fistulising perianal Crohn’s disease (CD) remains a debilitating condition, with few randomised controlled trials ...
gut.bmj

Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn’s disease

2 Nutritional Sciences Research Division, King’s College London, London, UK 3 Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark’s Campus, Harrow, UK ...
gut.bmj

Will worms really cure Crohn’s disease?

Correspondence to: Dr G Radford-Smith Department of Gastroenterology, Level 9A, Ned Hanlon Building, Royal Brisbane and Women’s Hospital, Herston 4029, Australia; graham_radford-smithhealth.qld.gov.au ...
gut.bmj

Acute pancreatitis: recent advances through randomised trials

Correspondence to Marc G Besselink, Department of Surgery, Amsterdam Gastroenterology and Metabolism, AMC Amsterdam, 22660, Amsterdam, The Netherlands; m.g.besselink{at}amc.uva.nl Acute pancreatitis ...
gut.bmj

P26 Elafibranor improves fatigue versus placebo in patients with primary biliary cholangitis (PBC), with limited correlation with pruritus: analyses from the phase III ELATIVE ...

1 Translational and Clinical Research Institute and NIHR Newcastle Biomedical Research Center, Newcastle University, Newcastle Upon Tyne, UK, Newcastle Upon Tyne, UK 2 Division of Gastroenterology and ...
gut.bmj

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has multifactorial aetiology with complex interactions between genetic and environmental factors. Over 150 ...
gut.bmj

PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial

3 Department of Paediatrics, Meander Medisch Centrum, Amersfoort, the Netherlands 4 MediServ BV/Clinical Research facilities BV, Schaijk, the Netherlands Correspondence to: Dr W P Voskuijl Department ...
gut.bmj

Dietary intake and the risk of gastro-oesophageal reflux disease: a cross sectional study in volunteers

1 Sections of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA 2 ...
gut.bmj

Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?

Intraventricular infusions of octopamine which raised brain octopamine concentrations more than 20 000-fold resulted in reductions in brain noradrenaline and dopamine by as much as 90% without ...