The distinct aging rates of neural progenitor cells and Wnt signaling dictate mammalian cortical layer proportions.

The canonical Wnt signaling pathway. The left panel (A) demonstrates the activated Wnt signaling cascade, while the right side portrays the inhibited Wnt signaling cascade. Wnt binds to the Fz ...

A pair of USC Stem Cell mouse studies detail how progenitor cells self-renew, differentiate, and aggregate into early kidney structures, offering insights for the creation of stem cell-based ...

Wnt signalling encompasses a family of secreted glycoproteins that orchestrate skeletal formation, remodelling and repair through two principal routes: the canonical (β-catenin-dependent) pathway and ...

The outer regions of the brain, the cortex, have specific layers of different cells—neurons—that are similarly ordered among all mammals, from tiny mouse brains to huge elephant brains. However, the ...

Researchers from the lab of Richard Simerly have uncovered the first example of activity-dependent development of hypothalamic neural circuitry. The work also suggests a novel role for the hunger ...

The hypothalamus is a small but critical region at the base of the brain that controls the autonomic nervous system, regulates body temperature, signals hunger and thirst, exerts hormonal control over ...