As we gear up for Week 16, which includes a doubleheader on Saturday, let's make sure you're sorted and have your wagers lined up before kickoff. Below, you can find our best bets of the week, along with picks for every game remaining on the slate.

Jacksonville is only 1-6 in its last seven games in Indianapolis. Fortunately for coach Liam Coen’s team, the Jaguars are changing a lot of trends in a positive way. Jacksonville has a top-five defense over the past four weeks and a notable special-teams edge in this matchup. That’s why I’m picking the Jaguars to win and cover.

Where would the Dallas Cowboys land in the 2026 NFL Draft if it were to be held today ahead of Sunday's Week 16 games?

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 15 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

The NFL playoff race continues in Week 16. Follow this live experience for today's coverage from The Athletic's writers.

The Dallas Cowboys add some much-needed defensive reinforcements in a new 2026 NFL mock draft following the team's elimination from the NFL playoffs in Week 16.