Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite ...
Macrophages are versatile immune cells, tasked with cleaning up pathogens and maintaining tissue health. But within the tumor microenvironment, they often shift into an M2-like state—one that ...
SPP1+ macrophages identified as key drivers and therapeutic targets in colorectal cancer progression
(A) Volcano plot of DEGs in monocytes/macrophages between NC and CRC samples in the GSE164552 dataset. (B) Venn diagrams of common DEGs up- or down-regulated across the six scRNA-seq datasets (NC vs.
Recent findings reveal Cornell prime dots can activate the immune system against melanoma, improving cancer immunotherapy ...
In a surprising twist on cellular metabolism, scientists have uncovered a noncanonical role of the metabolic enzymePHGDH in shaping immune responses within breast cancer microenvironment. Acting from ...
Phase II Study of Copanlisib in Patients With PTEN Loss: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols Z1G and Z1H AI-powered HER2 quantification continuous score (QCS) and tumor ...
2025, A Year of Momentum: Advancing Toward a Potential Breakthrough in Ovarian Cancer Treatment ...
A class of ultrasmall fluorescent core-shell silica nanoparticles developed at Cornell is showing an unexpected ability to ...
More than 90% of cancer deaths in America are attributable to metastasis, when cancer spreads from its original site to other parts of the body. Researchers at the Johns Hopkins Kimmel Cancer Center ...
“It really tells us it's not about the genetics [of the tumor],” said Joyce. “It's really about the microenvironment, and the brain microenvironment is profoundly more immune suppressive than in ...
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