To determine the relationship between telomerase activity and mammary tumor development, we harvested mammary glands from MMT mice at multiple time points and assayed for telomerase activity. A ...
New research linking telomere shortening to myelodysplastic syndromes (MDS) offers substantial therapeutic implications for affected patients and MDS research. In a previous study, the current authors ...
Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.
Telomere shortening, a chromosomal feature associated with cellular aging, is accelerated in immune cells from patients with rheumatoid arthritis (RA) compared with cells from healthy controls; ...
Pulmonary fibrosis—also known in technical terms as idiopathic pulmonary fibrosis (IPF)—is a rare but life-threatening ...
The stem terminus element (STE), which was discovered 13 y ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown. We report that the Schizosaccharomyces ...
Scientists investigate human telomere length to elucidate aging and diseases such as cancer and neurodegenerative disorders. In normal mammalian cells, a small telomeric DNA segment is lost after each ...
Telomeres, the non-coding ends of linear chromosomes, are thought to be an important mechanism of individual variability in performance. Research suggests that longer telomeres are indicative of ...
An RNA-based therapeutic approach led to transient activation of telomerase activity in a model of pulmonary fibrosis. A new report suggests that RNA-based human telomerase reverse transcriptase ...
Imagine your DNA as a set of shoelaces. Telomeres are like the plastic tips at the ends of those shoelaces, preventing them from fraying and unraveling. Structurally, telomeres are repetitive ...
A day in the life of DNA can be rough. It gets yanked across a dividing cell, zapped by radiation, and assaulted by chemicals. Luckily, cells have developed a complex set of repair mechanisms to ...
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