The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

Researchers at the Francis Crick Institute and the UCL Queen Square Institute of Neurology have developed DNA molecules which contain "invisibility cloak" sequences, preventing healthy cells from ...

28 March 2024, Leuven, Belgium — Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report ‘seeding’ this accumulation ...

AC Immune SA has synthesized thiazolo[5,4-c]pyridine-4(5H)-one derivatives acting as TAR DNA-binding protein 43 (TARDBP; TDP-43) aggregation ligands reported to be useful for the diagnosis of ...

Neurodegenerative diseases are a group of debilitating disorders characterized by progressive degeneration of nerve cells and a range of associated clinical symptoms, including motor, cognitive, and ...

Subscribe to our newsletter for the latest sci-tech news updates. Past neuroscience studies have identified a TAR DNA-binding protein that plays a key role in ALS, known as TDP-43. This protein, which ...

Problems with a protein known as TAR DNA-binding protein 43 (TDP-43) have long been associated with the neurodegenerative disorders Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS).

Aquinnah Pharmaceuticals Inc. has identified new TAR DNA-binding protein 43 (TARDBP; TDP-43) aggregation and microtubule-associated protein tau (PHF-tau; MAPT) aggregation inhibitors reported to be ...

A new artificial intelligence model can predict how different proteins may bind to DNA. A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, researchers report 'seeding' this accumulation through fragments of the ...