Loss of synapses and synapse function sit at the heart of a number of diseases, not just neurodegenerative examples such as dementia and Parkinson's disease but also conditions such as diabetes. We do ...

Astrocytes use the MEGF10 receptor to prune synapses in the striatum, a process essential for dopamine-driven motor learning.

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...

Leptin is a hormone released by fat cells in adult organisms, and researchers have largely focused on how it controls appetite. In a study published May 18 in Science Signaling, the authors show that ...

Scientists from Oregon Health & Science University (OHSU) and the University of Edinburgh have discovered that a little-understood junction that connects neurons to oligodendrocyte precursor cells ...

Researchers have found, for the first time, that a blood-clotting protein can, unexpectedly, degrade nerves--and how nerve-supporting glial cells, including Schwann cells, provide protection. The ...