The San Francisco 49ers versus the Tampa Bay Buccaneers is one of many strong options on the Week 6 NFL slate. With Week 6 in the NFL upon us, stay on top of the most current betting trends with our preview below.

The Buccaneers vs. Seahawks game kicks off at 4:05 p.m. ET/1:05 p.m. PT on Sunday, Oct. 5, 2025. The Week 5 game between the Buccaneers and the Seahawks will air on CBS, which means that if it's broadcast in your area, it'll also stream live on Paramount+. You can also tune in on mobile devices with NFL+.

Andrew McCarty is a breaking news writer for Athlon Sports, specializing in trending stories and real-time updates across the sports world. From the NFL and College Football to March Madness and the WNBA, he delivers fast, accurate coverage that keeps fans ahead of the curve.

The Seahawks are 9-1 on the road since they hired Mike Macdonald as coach. They'll hope to keep that up as four of their next six games are away from home.

Something is about to happen that does not occur often in the PNW: a Seahawks game and Mariners playoff game on the same day