A research project has successfully reproduced the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) from human iPS cells in vitro. Although cysts derived from renal tubules have ...

Sergio A. Giralt, MD, discusses how the pathophysiology of chronic graft-vs-host disease involves complex immune dysregulation, with CSF1R playing a crucial role in driving the differentiation of ...

Correspondence to Dr Lauren Pringels, Department of Physical and Rehabilitation Medicine, Ghent University Hospital, Ghent, Belgium; Lauren.Pringels{at}UGent.be Despite the high prevalence of tendon ...

Skin regeneration: Though less directly tied to rhinitis, external nasal defects from surgery or chronic inflammation can be ...

Patients with type 2 diabetes often have comorbid major depressive disorder, but the underlying neurobiological substrates are still poorly understood. The goal of this study was, therefore, to ...

Hypopituitarism is a health condition characterized by the reduced production of hormones from the pituitary gland. The pathophysiology of hypopituitarism usually involves damage to the pituitary ...

Considerable debate has surrounded the cause and underlying pathology of migraine and several theories have been proposed. The condition is generally thought to be of neurovascular origin, with ...

Please provide your email address to receive an email when new articles are posted on . Acute or chronic insult, including normal wear and tear, age, obesity, and joint injury, may initiate an ...

Like all forms of cancer, lung cancer is defined by uncontrolled cell division caused by loss of physiological tissue homeostasis and failure of apoptotic cell death mechanisms. Aberrant cell ...

The research in Singh laboratory is broadly focused on the pathophysiology of iron in disorders of the brain and the eye. Current interests in the lab include: Iron cycling in the eye. Pathophysiology ...