PURPOSE: To identify the role of p53 pathway alteration(s) as predictors of treatment outcome in patients with advanced, resectable, squamous cell carcinoma (SCC) of the larynx and pharynx treated ...
Oncotarget published "Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas" which reported that herein the authors evaluate expression of TAZ and YAP, the ...
Restoring P53's autonomous anti-cancer function through P53 mRNA delivery is a promising anti-tumor strategy. Yet, in tumors harboring mutant P53, the existing mutant P53 (Mutp53) would interferes ...
Scientists from Stanford University and the University of Texas MD Anderson Cancer Center have discovered a class of molecules that use endogenous proteins to modulate genetic pathways involved in ...
Scientists discover how the Fas-p53 pathway sabotages energy metabolism, offering new hope for tackling obesity and improving insulin sensitivity. Brief Communication: Expression of p53 in human ...
New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations
A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can ...
Scientists at The Wistar Institute have solved a longstanding puzzle in ovarian cancer treatment: why anti-estrogen therapy often fails even when tumors express the hormone receptor that should make ...
In a recent study published in the journal Science Advances, a large team of researchers in the United States examined the detrimental effects of ketogenic diets. The study used murine models and ...
A molecular switch in breast cancer cells reprograms the genetic production line towards tumor growth and stress resistance.
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