NFL Week 6 picks straight up and against spread
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Week 6 NFL game highlights
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When the 2025 NFL schedule came out in May, the Cleveland Browns should have filed a protest and asked the league to redo Week 6, because the Browns have been hit with a brutal scheduling quirk that only one other team in NFL history has ever had to face.
That isn't the case in Week 7. A gift from the football gods has given us a slate of games filled with high-profile quarterback matchups. From the Big Ten to the SEC, preseason standouts to midseason risers, it feels like every top passer will meet his match on Saturday.
Week 6 will conclude with another Monday Night Football doubleheader. The Buffalo Bills (4-1) will visit the Atlanta Falcons (2-2) and the Chicago Bears (2-2) will visit the Washington Commanders (3-2). The Houston Texans (2-3) and Minnesota Vikings (3-2) are on a bye in Week 6.
No. 3 Oregon and No. 7 Indiana are heading into their top-10 showdown on CBS as two of the three remaining unbeaten teams in the Big Ten. Something will have to give in a clash between programs led by Heisman contending quarterbacks and hard-charging head coaches.