Week 6 has plenty of intriguing matchups on deck, and already is off the heels of the New York Giants upsetting the Philadelphia Eagles on Thursday night. That just goes to show you that anything can unfold after kickoff,

Week 5 in the NFL featured several aspiring contenders showing cracks in composure, with the Cardinals and Bills among those losing their cool.

The Detroit Lions (4-1) take on the Kansas City Chiefs (2-3) on Sunday night for the first time since 2023. The Lions are two-point underdogs ahead of the game at Arrowhead Stadium, but Patrick Mahomes and the Chiefs are limping into the rematch after losing to the Jacksonville Jaguars (4-1) on Monday night.

After just five weeks, there are no undefeated teams left in the NFL. The Bills and the Eagles were the last two undefeated teams standing heading into Week 5, but they both lost on Sunday. This now marks just the fourth time since the AFL-NFL merger in 1970 that we'll be leaving Week 5 without a single undefeated team left in the league.

Jalen Hurts and the Philadelphia Eagles dropped a tough one on the road Thursday night, falling 34-17 to the New York Giants for their second straight loss and a 4-2 record.

New York Giants coach Brian Daboll apologized after shouting at the team doctor during Jaxson Dart’s concussion exam. The NFL said the incident is under review.

For the NFL Week 6 Thursday Night Football game of Eagles vs. Giants, the model is leaning Over the total, projecting 44 total points. It also says one side of the spread hits well over 60% of the time in an A-rated pick. See what it is at SportsLine.

When the Giants host the Eagles on Thursday night, one specific streak will be on the line. And the Giants will be hoping to end it. New York has lost eight straight NFC East games. It's currently the longest losing streak in division games for any NFL team.