Recently, Moncrieff and colleagues published a review of the evidence for the serotonin theory of depression, concluding that there was “no consistent evidence of there being an association between ...

The discovery of antidepressant drugs led to the first biochemical hypothesis of depression, known as the monoamine hypothesis. However, this hypothesis does not seem to fully explain the complexity ...

Princeton University researchers have observed a self-degradation response to the antidepressant Zoloft in yeast cells that could help provide new answers to lingering questions among scientists about ...

Researchers from Hiroshima University (HU), Japan, have proposed a new explanation for the biological mechanism behind depression, according to a study published in the journal Neuroscience. Currently ...

Nicotine & Tobacco Research, Vol. 3, No. 4 (November 2001), pp. 383-390 (8 pages) Previous studies have found that constituents in tobacco inhibit both forms of the enzyme monoamine oxidase (MAO-A and ...

The FDA approval and emergence of selective serotonin uptake inhibitors (SSRIs) in the late 1980s transformed psychiatry. Finally, there was an effective and inexpensive medication for depression, a ...

Despite the replacement of the monoamine hypothesis of depression with a more comprehensive understanding of multiple influencing factors in the pathology of depression, it is clear that elevating ...

Princeton University researchers have observed a self-degradation response to the antidepressant Zoloft in yeast cells that could help provide new answers to lingering questions among scientists about ...

For many years, the prevailing hypothesis of depression has been that a deficit in monoamine neurotransmitters, notably norepinephrine and serotonin, underlies depression. The monoamines are named ...