The NFL fixture computer has thrown up a sensational battle of two top teams as the Kansas City Chiefs take on the Buffalo Bills in Week 9 of the 2025 season. However, fans are worrying over the fitness of running back Isiah Pacheco,

The Bills picked up a first down after Josh Allen rushed for 11 yards, setting the Bills up near their own 40, where James Cook rushes past it. Second and seven for the Bills at their own 39. Dalton Kincaid picks up a first down on a 12-yard pass from Allen. But the drive stops and the Bills will punt, facing a fourth and nine.

Newsweek breaks down the Chiefs vs. Bills betting odds, injury news and best bets ahead of this afternoon's must-see matchup.

The Kansas City Chiefs, led by quarterback Patrick Mahomes, face the Buffalo Bills, led by quarterback Josh Allen, on Sunday, Nov. 2, 2025 at Highmark Stadium in Erie County, New York.

RB Isiah Pacheco was listed on the Chiefs' latest injury report. Here is an update on his status ahead of KC's Week 9 matchup against the Bills.

The Chiefs are going to battle against the Bills without two crucial players. Isiah Pacheco and Josh Simmons are ruled out.

The Kansas City Chiefs have been a difficult team to assess from a fantasy football perspective all season. They have a bit more clarity going into Week 9.

Trey Smith was listed on the Chiefs' latest injury report. Here is an update on his status ahead of KC's Week 9 matchup against the Buffalo Bills.

Josh Allen and the Buffalo Bills prepare to host Patrick Mahomes and the Kansas City Chiefs in a rematch of last season’s AFC championship game.

Washington Commanders' defense has struggled, but analysts warn against starting one specific Chiefs WR in Week 8. Find out why, plus the verdict on Marcus Mari