Homologous recombination is one mechanism for repairing double-stranded DNA breaks. It involves the exchange of nucleotide sequences to repair damaged bases on both strands of DNA through the ...
Eight hundred and six patients were randomly assigned (2:1). Tumors were analyzed using the Myriad MyChoice HRD Plus assay to assess non–BRCA HRRm and HRD status; HRD was based on a genomic ...
Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, ...