Evaluation of potential hepatotoxicity, a detailed knowledge of plasma proteins in physiological and pathological states, and identification of biomarkers and effective interventions can all ...
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in ...
DILI is broadly categorized into intrinsic and idiosyncratic types. Intrinsic hepatotoxins, such as APAP, cause dose-dependent injury, while idiosyncratic DILI involves complex immune and metabolic ...
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