A rat with some human genes could provide a better way to test Alzheimer's drugs. The genetically modified rat is the first rodent model to exhibit the full range of brain changes found in Alzheimer's ...

Using the blastocyst complementation method, we produced rat embryonic stem (ES) cell-derived sperm in testicular hypoplasia mice and successfully generated rat offspring. This method can provide a ...

In a striking demonstration of targeted knockout rats, scientists used zinc finger nucleases to deactivate a green fluorescent protein (GFP) transgene, which causes the rats to appear green under ...

Resulting animals had permanent heritable mutations, according to paper in Science. A group of scientists report the creation of the first genetically modified rats using Sangamo Biosciences zinc ...