Using a powerful single-molecule imaging method they developed, a Broad Institute research team has unveiled a dynamic view ...

Membrane receptors and transporters translate extracellular cues into cellular responses by harnessing conformational changes, ion flux or enzymatic activity. Fast-acting ligand-gated ion channels ...

A study led by researchers at the University of Liège reveals the mechanism by which surfactin, a molecule produced by ...

Researchers found that mice lacking membrane ERα signaling in osteoblast lineage cells had significantly lower cortical bone mass, highlighting the pathway’s critical role in maintaining the strength ...

The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

Taste, pain, or response to stress -- nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers have uncovered the ...

FUJIFILM Corporation announced today that it has developed an innovative screening methodology for cyclic peptides exhibiting high affinity toward membrane proteins1. This new technology enables ...

Building on an in vivo genetic screen in mice to identify host regulators of cancer metastasis, 4 Yang et al. focused on ARHGEF1, which is 1 of 15 genes whose disruption in host tissues decreases the ...