For many people who have bipolar I, lithium is that most elusive of pharmacological treatments, the “magic bullet”—a single intervention that completely eliminates the symptoms of a disease. Since the ...

Pharmacotherapy for early-onset bipolar disorder is one of the least studied areas of child and adolescent psychopharmacology. Although there are numerous well-controlled trials evaluating the safety ...

Changes Clinical Practice: Based on this large trial, lithium alone or a lithium-valproate combination should be used as first-line maintenance treatment for bipolar affective disorder type I instead ...

Hayes et al 12 conducted one of the most recent large studies to compare lithium with newer second-generation antipsychotics as maintenance monotherapy for bipolar disorder. The authors concluded that ...

Can lithium’s effect on daily activity patterns reveal who will benefit from treatment? A six-week trial finds circadian shifts emerge early, before mood improves, hinting at a biological clue to ...

While lithium treatment has proven to be a godsend for many of the two million Americans with bipolar disorder, it is not without its downside. People on the drug may develop hypothyroidism, tremors, ...

Forbes contributors publish independent expert analyses and insights. I write about the brain, public health, or both at the same time. Lithium is often the first treatment option for bipolar disorder ...

Doctors have observed and treated bipolar disorder for thousands of years. Known throughout history by many names, like depression, mania, manic-depressive illness, or psychosis, the disorder is ...

Each month, The Clinical Advisor makes one new clinical feature available ahead of print. Don’t forget to take the poll. The results will be published in the next month’s issue. Bipolar disorder is a ...